Combination Therapy for Acute Ischemic Stroke Is Safe and Warrants Larger Study, Researchers Find

Share

CINCINNATI—The combination of the clot-busting drug tPA with an infusion of the antiplatelet drug eptifibatide is safe and warrants a larger study to demonstrate it improves outcome after acute ischemic stroke, a study led by University of Cincinnati (UC) researchers has found.

The study, known as the CLEAR-ER Stroke Trial, was sponsored by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) as a Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) project. Results were presented today (Thursday, Feb. 7) at the American Heart Association/American Stroke Association’s International Stroke Conference in Honolulu by Opeolu Adeoye, MD, Assistant Professor of Emergency Medicine and Neurosurgery at UC and a neurointensivist at UC Medical Center.

UC was the coordinating center for the trial, which included nine medical centers comprising 21 hospitals. Adeoye was co-principal investigator along with Arthur Pancioli, MD, professor and Richard C. Levy Chair for Emergency Medicine at UC. Both Adeoye and Pancioli are members of the UC Neuroscience Institute, one of four institutes affiliated with the UC College of Medicine and UC Health.

Standard treatment for acute ischemic stroke (characterized by an obstruction to the blood flow, typically a clot), is intravenous (IV) delivery of U.S. Food and Drug Administration-approved tissue plasminogen activator (tPA) within three hours of stroke onset.

“We know that the combination of these two medications dissolves clots faster and more completely than tPA alone,” Dr. Pancioli says. “Our goal is to determine if we can use this combination to improve the outcomes for acute stroke victims.”

Learn more >>

This entry was posted in Press Releases and tagged , , , , , , , . Bookmark the permalink. Both comments and trackbacks are currently closed.
  • Print This Page
  • Make an Appointment: Schedule Now
  • UCNI Weekly Blog
  • Join Our Email List
    for Bi-Monthly Updates

    Click here to continue.
  • Hope Stories

    • Leah’s Story: Arteriovenous Malformation (AVM)

      Leah's Story: Arteriovenous Malformation (AVM)Leah is a young woman who sings, dances, and plays the guitar. She is also a survivor of an arteriovenous malformation (AVM). It is rare for someone in her mid-teens to have had an AVM, an abnormal tangle of blood vessels...
    • Charlie’s Story: Epilepsy

      Charlie's Story: EpilepsyBy Charlie Shor I have had many adventures in my 57 years, and I have accomplished much. But the main message of my story, which I have been given the opportunity to share, is that anything is possible. If you have...
    • Dr. Mike’s Story: Glioblastoma

      Dr. Mike's Story: Glioblastoma Sixteen months after receiving a diagnosis of brain cancer, Dr. Michael Wood continues to attack his disease with wellness. In addition to surgery, radiation, chemotherapy and strong family support, the 61-year-old Cincinnati otolaryngologist has worked hard to provide his own...
    • Courtney’s Story: Traumatic Spine Injury

      Courtney's Story: Traumatic Spine Injury Courtney is positive that she was wearing her seatbelt. Perhaps that is why her head and neck – thankfully -- were fine. Perhaps that is also why her midsection was so violently impacted, as the force of the rollover twisted...
    • Tim’s Story: Traumatic Brain Injury

      Tim's Story: Traumatic Brain Injury This story includes a graphic description of Tim’s traumatic brain injury. If you are squeamish or faint of heart, you may wish to close this file and turn to a different story of hope.   Tim was outdoors doing what he liked...
    • Jim’s Story: Pituitary Tumor

      Jim's Story: Pituitary Tumor One turn of events led to another, and so it was that Jim, and not his wife, took Jim’s 87-year-old father to his appointment with the dermatologist for the first time. And so it was that the dermatologist was not...
    • David’s Story: Stroke

      David's Story: Stroke A few years ago, on a day that had begun like any other, David stood up to leave a restaurant following lunch and was hit by a gentle wave of dizziness. Unaware that he was suffering a stroke, David took...
    • Kevin’s Story: Acoustic Neuroma

      Kevin's Story: Acoustic Neuroma Kevin was in his mid-40s when he began to notice that he wasn’t hearing quite as well as in the past. But the change was gradual, so he didn’t worry about it. A few years went by, and the hearing...
    • Mike’s Hope Story: Parkinson’s disease

      Imagine learning you have Parkinson’s Disease. At 26. Most Parkinson’s patients are diagnosed in their 60s. Yet in 1987, after three years of unexplained symptoms, Mike Pohl learned he had the degenerative disease. After a visit to the National Institutes...
    • Frank’s Story: Parkinson’s Disease

      Frank's Story: Parkinson's DiseaseSome people have vacation homes. Frank has the UC Neuroscience Institute. This is where he comes for comprehensive, compassionate medical care for Parkinson’s disease, which he has lived with for 15 years. “They make us feel safe,” says Frank’s wife, Sandy....