Combination Therapy for Acute Ischemic Stroke Is Safe and Warrants Larger Study, Researchers Find

Share

CINCINNATI—The combination of the clot-busting drug tPA with an infusion of the antiplatelet drug eptifibatide is safe and warrants a larger study to demonstrate it improves outcome after acute ischemic stroke, a study led by University of Cincinnati (UC) researchers has found.

The study, known as the CLEAR-ER Stroke Trial, was sponsored by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) as a Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) project. Results were presented today (Thursday, Feb. 7) at the American Heart Association/American Stroke Association’s International Stroke Conference in Honolulu by Opeolu Adeoye, MD, Assistant Professor of Emergency Medicine and Neurosurgery at UC and a neurointensivist at UC Medical Center.

UC was the coordinating center for the trial, which included nine medical centers comprising 21 hospitals. Adeoye was co-principal investigator along with Arthur Pancioli, MD, professor and Richard C. Levy Chair for Emergency Medicine at UC. Both Adeoye and Pancioli are members of the UC Neuroscience Institute, one of four institutes affiliated with the UC College of Medicine and UC Health.

Standard treatment for acute ischemic stroke (characterized by an obstruction to the blood flow, typically a clot), is intravenous (IV) delivery of U.S. Food and Drug Administration-approved tissue plasminogen activator (tPA) within three hours of stroke onset.

“We know that the combination of these two medications dissolves clots faster and more completely than tPA alone,” Dr. Pancioli says. “Our goal is to determine if we can use this combination to improve the outcomes for acute stroke victims.”

Learn more >>

This entry was posted in Press Releases and tagged , , , , , , , . Bookmark the permalink. Both comments and trackbacks are currently closed.
  • Print This Page
  • Make an Appointment: Schedule Now
  • UCNI Weekly Blog
  • Join Our Email List
    for Bi-Monthly Updates

    Click here to continue.
  • Hope Stories

    • Sandra’s Story Glioma

      Sandra's Story Glioma Sandra (Sandy) is a smiling, breathing reminder that hope exists for patients with even the most challenging type of brain tumors. Nine years ago, when Sandy was first told that she had six months to live, she stared back blankly...
    • Jeff’s Story: Ruptured Aneurysm, Airway Reconstruction

      Jeff's Story: Ruptured Aneurysm, Airway Reconstruction Jeff’s remarkable story has two parts: recovery and reconstruction. He doesn’t remember the first part -- the recovery from a ruptured aneurysm. But he vividly remembers the second part -- the reconstruction of his airway. He is living the followup to...
    • Brian’s Story: Vocal Cord Cyst

      Brian's Story: Vocal Cord Cyst One by one, the symptoms of a throat problem tapped on the pastor’s door. Pastor Brian Tome, leader of Crossroads Church and speaker of five weekly messages to a following of 15,000, acknowledged the symptoms and tried to dismiss them....
    • Matt’s Story: Head Injury

      Matt's Story: Head Injury A poor decision nearly cost Matt his life. But state-of-the-art neurosurgical and neurocritical care, dedicated therapists, and family support gave him a chance to start over again. Today, in what is proving to his best decision ever, Matt is studying...
    • Amber’s Story: Ruptured Aneurysm

      Amber's Story: Ruptured Aneurysm The only visible sign of Amber Gray’s ordeal is the long slender scar that runs along her forearm. It is the area where a surgeon carefully removed her radial artery, which was needed to bypass a damaged artery in her...
    • Christine’s Story: Stroke

      Christine's Story: StrokeThere was a sliver of a chance, maybe, and most likely the emergency room doctor thought there was no chance at all. Christine had arrived at the community hospital comatose, brought by her parents, who had come home after working...
    • Courtney’s Story: Traumatic Spine Injury

      Courtney's Story: Traumatic Spine Injury Courtney is positive that she was wearing her seatbelt. Perhaps that is why her head and neck – thankfully -- were fine. Perhaps that is also why her midsection was so violently impacted, as the force of the rollover twisted...
    • Joe’s Story: Oligodendroglioma

      Joe's Story: Oligodendroglioma Joe calls it a miracle and a gift from “a higher power.” Others might call it a fortuitous turn of fate. Either way, Joe’s experience embodies a reversal of fortune that is both wonderful and startling. Once a man with...
    • Charlie’s Story: Epilepsy

      Charlie's Story: EpilepsyBy Charlie Shor I have had many adventures in my 57 years, and I have accomplished much. But the main message of my story, which I have been given the opportunity to share, is that anything is possible. If you have...
    • Alicia’s Story: Multiple Sclerosis

      Alicia’s Story: Multiple Sclerosis Alicia is living a life that is filled to the brim: she is a wife, a mother, a runner, and the owner and manager of an up-tempo restaurant that specializes in fresh, healthy, locally sourced food. She is also a...